Laboratory Values for Clinical Investigations

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These values summarize most of the laboratory values needed for investigations

Haematological values
Reference range
Analysis SI units Non-SI units
Bleeding time (Ivy) < 8 mins -
Blood volume
Male 75 ± 10 mL/kg -
Female 70 ± 10 mL/kg -
Coagulation screen
Prothrombin time 10.5-13.5 secs -
Activated partial thromboplastin time 26-36 secs -
D-dimers
To detect disseminated intravascular coagulation < 200 μg/L < 200 ng/mL
To detect venous thromboembolism < 500 μg/L < 500 ng/mL
Erythrocyte sedimentation rate Higher values in older patients are not necessarily abnormal
Adult male 0-10 mm/hr -
Adult female 3-15 mm/hr -
Ferritin
Male 20-300 μg/L 20-300 ng/mL
Female 14-150 μg/L 14-150 ng/mL
Fibrinogen 1.5-4.0 g/L 0.15-0.4 g/dL
Folate
Serum 5.0-20 μg/L 5.0-20 ng/mL
Red cell 257-800 μg/L 257-800 ng/mL
Haemoglobin
Male 130-180 g/L 13-18 g/dL
Female 115-165 g/L 11.5-16.5 g/dL
Haptoglobin 0.4-2.4 g/L 0.04-0.24 g/dL
Iron 10-32 μmol/L 56-178 μg/dL
Leucocytes (adults) 4.0-11.0 × 109/L 4.0-11.0 × 103/mm3
Differential white cell count
Neutrophil granulocytes 2.0-7.5 × 109/L 2.0-7.5 × 103/mm3
Lymphocytes 1.5-4.0 × 109/L 1.5-4.0 × 103/mm3
Monocytes 0.2-0.8 × 109/L 0.2-0.8 × 103/mm3
Eosinophil granulocytes 0.04-0.4 × 109/L 0.04-0.4 × 103/mm3
Basophil granulocytes 0.01-0.1 × 109/L 0.01-0.1 × 103/mm3
Mean cell haemoglobin (MCH) 27-32 pg -
Mean cell volume (MCV) 78-98 fl -
Packed cell volume (PCV) or haematocrit
Male 0.40-0.54 -
Female 0.37-0.47 -
Platelets 150-350 × 109/L 150-350 × 103/mm3
Red cell count
Male 4.5-6.5 × 1012/L 4.5-6.5 × 106/mm3
Female 3.8-5.8 × 1012/L 3.8-5.8 × 106/mm3
Red cell lifespan
Mean 120 days -
Half-life (51Cr) 25-35 days -
Reticulocytes (adults) 25-85 × 109/L 25-85 × 103/mm3
Transferrin 2.0-4.0 g/L 0.2-0.4 g/dL
Transferrin saturation
Male 25-56% -
Female 14-51% -
Vitamin B12 251-900 ng/L -

 

Cerebrospinal fluid analysis
Reference range
Analysis SI units Non-SI units
Cells < 5 × 106 cells/L (all mononuclear) < 5 cells/mm3
Glucose1 2.3-4.5 mmol/L 41-81 mg/dL
IgG index2 < 0.65 -
Total protein 140-450 mg/L 0.014-0.045 g/dL
1Interpret in relation to plasma glucose. Values in CSF typically approximately two-thirds plasma levels.
2A crude index of increase in IgG attributable to intrathecal synthesis.

 

Common analytes in urine
Reference range
Analyte SI units Non-SI units
Albumin Proteinuria is defined below
Calcium (normal diet) Up to 7.5 mmol/24 hrs Up to 15 meq/24 hrs or 3-300 mg/24 hrs
Copper < 0.6 μmol/24 hrs < 38 μg/24 hrs
Cortisol
Overnight (early morning sample) < 20 nmol cortisol/mmol creatinine < 67 μg cortisol/g creatinine
24-hr collection 25-250 nmol/24 hrs 9.1-91 μg/24 hrs
Creatinine 10-20 mmol/24 hrs 1130-2260 mg/24 hrs
5-hydroxyindole-3-acetic acid (5-HIAA) 10-42 μmol/24 hrs 1.9-8.1 mg/24 hrs
Metadrenalines
Normetadrenaline 0.4-3.4 μmol/24 hrs 73-620 μg/24 hrs
Metadrenaline 0.3-1.7 μmol/24 hrs 59-335 μg/24 hrs
Oxalate 0.04-0.49 mmol/24 hrs 3.6-44 mg/24 hrs
Phosphate 15-50 mmol/24 hrs 465-1548 mg/24 hrs
Potassium* 25-100 mmol/24 hrs 25-100 meq/24 hrs
Protein < 0.3 g/L < 0.03 g/dL
Sodium* 100-200 mmol/24 hrs 100-200 meq/24 hrs
Urate 1.2-3.0 mmol/24 hrs 202-504 mg/24 hrs
Urea 170-600 mmol/24 hrs 10.2-36.0 g/24 hrs

 

Other common analytes in venous blood in adults
Reference range
Analyte SI units Non-SI units
α1-antitrypsin 1.1-2.1 g/L 110-210 mg/dL
Alanine aminotransferase (ALT) 10-50 U/L -
Albumin 35-50 g/L 3.5-5.0 g/dL
Alkaline phosphatase 40-125 U/L -
Amylase < 100 U/L -
Aspartate aminotransferase (AST) 10-45 U/L -
Bilirubin (total) 3-16 μmol/L 0.18-0.94 mg/dL
Calcium (total) 2.1-2.6 mmol/L 4.2-5.2 meq/L or 8.50-10.50 mg/dL
Carboxy-haemoglobin 0.1-3.0% -
Caeruloplasmin 0.2-0.6 g/L 20-60 mg/dL
Cholesterol (total) Ideal level varies according to cardiovascular risk so reference ranges can be misleading. The following values were described by the European Atherosclerosis Society:
Mild increase
5.2-6.5 mmol/L 200-250 mg/dL
Moderate increase
6.5-7.8 mmol/L 250-300 mg/dL
Severe increase
> 7.8 mmol/L > 300 mg/dL
HDL-cholesterol Ideal level varies according to cardiovascular risk so reference ranges can be misleading. According to the National Cholesterol Education Programme Adult Treatment Panel III (ATPIII), a low HDL-cholesterol is:
< 1.0 mmol/L < 40 mg/dL
Complement
C3 0.73-1.4 g/L -
C4 0.12-0.3 g/L -
Total haemolytic complement 0.086-0.410 g/L -
Copper 13-24 μmol/L 83-153 μg/dL
C-reactive protein < 5 mg/L
Highly sensitive CRP assays also exist which measure lower values and may be useful in estimating cardiovascular risk
Creatine kinase (total)
Male 55-170 U/L -
Female 30-135 U/L -
Creatine kinase MB isoenzyme < 6% of total CK -
Ethanol Not normally detectable
Marked intoxication
65-87 mmol/L 300-400 mg/dL
Stupor
87-109 mmol/L 400-500 mg/dL
Coma
> 109 mmol/L > 500 mg/dL
Gamma-glutamyl transferase (GGT) Male 10-55 U/L
Female 5-35 U/L
-
Glucose (fasting) 3.6-5.8 mmol/L 65-104 mg/dL
Glycated haemoglobin (HbA1c) 4.0-6.0%
20-42 mmol/mol Hb
-
Immunoglobulins (Ig)
IgA 0.8-4.5 g/L -
IgE 0-250 kU/L -
IgG 6.0-15.0 g/L -
IgM 0.35-2.90 g/L -
Lactate 0.6-2.4 mmol/L 5.40-21.6 mg/dL
Lactate dehydrogenase (total) 208-460 U/L -
Lead < 1.0 μmol/L < 21 μg/dL
Magnesium 0.75-1.0 mmol/L 1.5-2.0 meq/L or 1.82-2.43 mg/dL
Osmolality 280-296 mmol/kg -
Osmolarity 280-296 mosm/L -
Phosphate (fasting) 0.8-1.4 mmol/L 2.48-4.34 mg/dL
Protein (total) 60-80 g/L 6-8 g/dL
Triglycerides (fasting) 0.6-1.7 mmol/L 53-150 mg/dL
Troponins Values consistent with ‘myocyte necrosis’ or myocardial infarction are crucially dependent upon which troponin is measured (I or T) and on the method employed
Tryptase 0-135 mg/L -
Urate
Male 0.12-0.42 mmol/L 2.0-7.0 mg/dL
Female 0.12-0.36 mmol/L 2.0-6.0 mg/dL
Vitamin D
25(OH)D 25-170 nmol/L 10-68 ng/mL
1,25(OH)2D 20-120 pmol/L 7.7-46 pg/mL
Zinc 11-22 μmol/L 72-144 μg/dL

 

Hormones in venous blood
Reference range
Hormone SI units Non-SI units
Adrenocorticotrophic hormone (ACTH) (plasma) 1.5-11.2 pmol/L (0700-1000 hrs) 7-51 pg/mL
Aldosterone
Supine 30-440 pmol/L 1.09-15.9 ng/dL
Erect 110-860 pmol/L 3.97-31.0 ng/dL
Cortisol Dynamic tests are required
Follicle-stimulating hormone (FSH)
Male 1.0-10.0 U/L 0.2-2.2 ng/mL
Female 3.0-9.0 U/L (early follicular, luteal) 0.7-2.0 ng/mL
< 30 U/L (mid-cycle) < 6.7 ng/mL
> 30 U/L (post-menopausal) > 6.7 ng/mL
Gastrin (plasma, fasting) < 57 pmol/L < 120 pg/mL
Growth hormone (GH) < 0.5 μg/L excludes acromegaly (if IGF1 in reference range) -
> 6 μg/L excludes GH deficiency
Dynamic tests are usually required
Insulin Highly variable and interpretable only in relation to plasma glucose and body habitus -
Luteinising hormone (LH)
Male 1.0-9.0 U/L 0.11-1.0 μg/L
Female 2.5-9.0 U/L (early follicular, luteal) 0.3-1.0 μg/L
Up to 90 U/L (mid-cycle) Up to 10 μg/L
> 20 U/L (post-menopausal) > 2.2 μg/L
17β-Oestradiol
Male < 160 pmol/L < 43 pg/mL
Female 110-180 pmol/L (early follicular) 30-49 pg/mL
550-2095 pmol/L (mid-cycle) 150-570 pg/mL
370-770 pmol/L (luteal) 101-209 pg/mL
< 150 pmol/L (post-menopausal) < 41 pg/mL
Parathyroid hormone (PTH) 1.0-6.5 pmol/L 10-65 pg/mL
Progesterone
Male < 2.0 nmol/L < 0.63 ng/mL
Female < 2.0 nmol/L (follicular) < 0.63 ng/mL
> 15 nmol/L (mid-luteal) > 4.7 ng/mL
< 2.0 nmol/L (post-menopausal) < 0.63 ng/mL
Prolactin (PRL) 60-500 mU/L -
Renin activity
Erect 1.0-4.2 ng/mL/hr -
Supine 0.5-2.6 ng/mL/hr -
Testosterone
Male 10-30 nmol/L 2.88-8.64 ng/mL
Female 0.4-3.0 nmol/L 0.12-0.87 ng/mL
Thyroid-stimulating hormone (TSH) 0.2-4.5 mU/L -
Thyroxine (free) (free T4) 9-21 pmol/L 700-1632 pg/dL
Triiodothyronine (T3) 0.9-2.4 nmol/L 59-156 ng/dL

Notes

  1. A number of hormones are unstable and collection details are critical to obtaining a meaningful result. Refer to local laboratory handbook.
  2. Values in the table are only a guideline; hormone levels can often only be meaningfully understood in relation to factors such as sex (e.g. testosterone), age (e.g. FSH in women), time of day (e.g. cortisol) or regulatory factors (e.g. insulin and glucose, PTH and [Ca2+]).
  3. Reference ranges may be critically method-dependent.

Urea and electrolytes in venous blood

Reference range
Analysis SI units Non-SI units
Sodium 135-145 mmol/L 135-145 meq/L
Potassium (plasma) 3.3-4.7 mmol/L 3.3-4.7 meq/L
Potassium (serum) 3.6-5.1 mmol/L 3.6-5.1 meq/L
Chloride 95-107 mmol/L 95-107 meq/L
Urea 2.5-6.6 mmol/L 15-40 mg/dL
Creatinine 60-120 μmol/L 0.68-1.36 mg/dL
Arterial blood analysis
Reference range
Analysis SI units Non-SI units
Bicarbonate 21-29 mmol/L 21-29 meq/L
Hydrogen ion 37-45 nmol/L pH 7.35-7.43
Pa CO2 4.5-6.0 kPa 34-45 mmHg
Pa O2 12-15 kPa 90-113 mmHg
Oxygen saturation > 97%

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